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impacts on community health and the related economic indicators Quality-assured, safe and effective medicines, vaccines and medical devices are fundamental to a functioning health system Other patterns of drug resistance There were an estimated 1 5 million incident cases (95% UI: 0 59–2 4 million) of isoniazid-resistant TB in 2024, including people with both rifampicin-susceptible and rifampicin-resistant TB The use of psychoactive drugs without medical supervision is associated with significant health risks and can lead to the development of drug use disorders Drug use disorders, particularly when untreated, increase morbidity and mortality risks for individuals, can trigger substantial suffering and lead to impairment in personal, family, social, educational, occupational or other important About WHO Drug Information WHO Drug Information is a quarterly journal providing an overview of topics relating to medicines development and regulation which is targeted to a wide audience of 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